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Article: Later cART initiation in migrant men from sub-Saharan Africa without advanced HIV disease in France.

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de Monteynard LA; Dray-Spira R; de Truchis P; Grabar S; Launay O; Meynard JL; Khuong-Josses MA; Gilquin J; Rey D; Simon A; Pavie J; Mahamat A; Matheron S; Costagliola D; Abgrall S
PLoS ONE, 2015


10.1371/journal.pone.0118492.t001 Characteristics of the individuals at enrolment and at cART initiation, N = 13338.
All individuals FRAa SSA/NFWb OTHc p
N = 13338 N = 9605 N = 2873 N = 860
At enrolment
Gender and HIV transmission group
MSM 5515 (41.4) 5058 (52.7) 68 (2.4) 389 (45.2)
Heterosexual men 2795 (21.0) 1599 (16.6) 1008 (35.1) 188 (21.9)
Heterosexual women 3606 (27.0) 1873 (19.5) 1569 (54.6) 164 (19.1)
IDU men 280 (2.1) 227 (2.4) 6 (0.2) 47 (5.5)
IDU women 86 (0.6) 74 (0.8) 3 (0.1) 9 (1.0)
Other men 694 (5.2) 554 (5.7) 90 (3.1) 50 (5.8)
Other women 362 (2.7) 220 (2.3) 129 (4.5) 13 (1.5) <0.0001
Age [years]
<30 3712 (27.8) 2519 (26.2) 935 (32.5) 258 (30.0)
30-39 5124 (38.4) 3669 (38.2) 1140 (39.7) 315 (36.6)
40-49 2948 (22.1) 2221 (23.1) 546 (19.0) 181 (21.1)
≥50 1554 (11.7) 1196 (12.5) 252 (8.8) 106 (12.3) <0.0001
Enrolment period
2002-2005 6902 (51.8) 4882 (50.8) 1604 (55.8) 416 (48.4)
2006-2007 2927 (21.9) 2100 (21.9) 635 (22.1) 192 (22.3)
2008-2010 3509 (26.3) 2623 (27.3) 634 (22.1) 252 (29.3) <0.0001
Region of care
Paris area 7360 (55.2) 4799 (50.0) 1996 (69.5) 565 (65.7)
Southern France 1193 (8.9) 1023 (10.6) 90 (3.1) 80 (9.3)
Other/Reunion island 4122 (30.9) 3397 (35.4) 577 (20.1) 148 (17.2)
French West Indies 663 (5.0) 386 (4.0) 210 (7.3) 67 (7.8) <0.0001
CD4 cell count [/μL] 431 (316-588) 450 (330-610) 375 (282-508) 435 (313-590) <0.0001
Plasma viral Load [log10 copies/mL] 4.42 (3.78-4.95) 4.47 (3.85-5.00) 4.24 (3.58-4.78) 4.46 (3.89-4.92) <0.0001
Hepatitis B antigen
Negative 9999 (75.0) 6875 (71.6) 2407 (83.8) 717 (83.4)
Positive 835 (6.3) 316 (3.3) 231 (8.0) 36 (4.2)
Unknown 2756 (20.6) 2414 (25.1) 235 (8.2) 107 (12.4) <0.0001
Hepatitis C antibodies
Negative 9966 (74.7) 6767 (70.4) 2533 (88.2) 666 (77.4)
Positive 835 (6.3) 633 (6.6) 103 (3.6) 99 (11.5)
Unknown 2537 (19.0) 2205 (23.0) 237 (8.2) 95 (11.1) <0.0001
At cART initiation N = 8543 N = 6156 N = 1845 N = 542
CD4 cell count [/μL] 309 (246-405 319 (252-419) 284 (229-361) 295 (235-394) <0.0001
Plasma viral Load [log10 copies/mL] 4.65 (3.95-5.14) 4.70 (4.00-5.17) 4.50 (3.80-5.00) 4.77 (4.19-5.12) <0.0001
AIDS status 145 (1.7) 88 (1.4) 45 (2.4) 12 (2.2) 0.0082

Data are counts (proportions) and medians (interquartile range).

a Including French West Indies.

b Including non-French West Indies.

c Including Northern Africa, Asia, Oceania, Australia, North America, Central and South America, Middle East, Western Europe and Eastern Europe.

Abbreviations: FRA, French natives; SSA, sub-Saharan Africa; NFW, non-French West Indies; OTH, Other regions of the world; MSM, Men who have sex with men; IDU, Injecting drug user, cART, combination antiretroviral therapy;


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